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Metsafe (Metformin)

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Metsafe is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain and is taken by mouth.

Other names for this medication:
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Also known as: Metformin


Metsafe (metformin) is an oral diabetes medicine that helps control blood sugar levels.

Metsafe is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Metsafe is sometimes used together with insulin or other medications, but metformin is not for treating type 1 diabetes.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take Metsafe XR with a meal, unless your doctor tells you otherwise. Some forms of metformin are taken only once daily with the evening meal. Follow your doctor's instructions.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Metsafe XR is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Your doctor may have you take extra vitamin B12 while you are taking Metsafe XR. Take only the amount of vitamin B12 that your doctor has prescribed.

Detailed Metsafe XR dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Metsafe are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Metsafe if you are allergic to Metsafe components. Try to be careful with Metsafe while you are pregnant or have nurseling. Metsafe can't be used by patients under 10 years. Metsafe XR (extended-release tablets) can't be used by patients under 17 years. Metsafe is not taken to treat type 1 diabetes. You can normally take insulin while using Metsafe. Do not use Metsafe in case of taking probenecid (Benemid); aspirin and other salicylates; sulfa drugs (Bactrim); beta-blockers; monoamine oxidase inhibitor (MAOI); allergies, colds, asthma medicines; thyroid medicine (Synthroid); seizure medicines (Dilantin); phenothiazines (Compazine); diet pills; isoniazid; steroids; hormones including birth control pills. Try to be careful with Metsafe in case of using such medication as morphine (MS Contin, Kadian, Oramorph); quinidine (Cardioquin, Quinidex, Quinaglute); vancomycin (Vancocin, Lyphocin); cimetidine (Tagamet) or ranitidine (Zantac); nifedipine (Adalat, Procardia); procainamide (Procan, Pronestyl, Procanbid); trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra); amiloride (Midamor) or triamterene (Dyrenium); digoxin (Lanoxin); furosemide (Lasix). Try to avoid Metsafe in case of having lung, kidney, heart or liver disease, high blood pressure, stroke, diabetic ketoacidosis, or kidney failure. Try to avoid Metsafe in case you want to undergo an operation (dental or any other), x-ray or CT scan. Try to avoid unhealthy food. Metsafe can't be used by patients under 10 years. Metsafe XR (extended-release tablets) can't be used by patients under 17 years. If you want to achieve most effective results without any side effects you need to avoid alcohol. It can be dangerous to stop Metsafe taking suddenly.

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Experimental tests are the basis for constitutive formulation, with a view to numerical modelling for investigation of the interaction between the tissues and a prosthesis. Prevalence and characterization of ultrasound lesions with correlation to histology were evaluated. Inhibition of the development of tolerance to morphine in rats by drugs which inhibit ribonucleic acid or protein synthesis. Our own results show that papillary renal cell carcinoma displays considerable similarities to proximal tubular progenitor cells and we suggest that this tumor form may develop in a multi-step fashion via benign renal adenomas. The design and characterization of a testing platform for quantitative evaluation of tread performance on multiple biological substrates. In small-RNA sequencing, the microRNA (miRNA) content differed widely between samples owing to competitive sequencing of rRNA fragments. Herein, kinase activities seem to play an important role in Treg fine tuning. The disturbance of cholesterol biosynthesis could have adverse impact on fatty acid metabolism, consequently induce the decrease of carnitine and increase of acylcarnitines in treated groups. Participants perceived a number of physical, functional, and psychological benefits.

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